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HIV information

Protein name HIV ProteinID HIV Protein Description
Pr55(Gag) NP_057850 HIV-1 Gag binds to AP-2, and this binding is dependent on tyrosine residue 132 and valine residue 135 at the matrix-capsid junction in the Gag polyprotein
Vif NP_057851 Vif plays an important role in promoting HIV-1 binding to CD4
Vpr NP_057852 HIV-1 Vpr-expressing Jurkat T cell clones showed a significant increase in G-actin polymerization to filamentous actin (F-actin), indicating a role of Vpr in microfilament system assembly. Vpr also causes disruption of the actin cytoskeleton in yeast.
Tat NP_057853 Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein
Rev NP_057854 Rev plays an important role in the compartmentation of translation by directing RRE-containing mRNAs to the beta-actin to form the perinuclear clusters at which the synthesis of viral structural proteins begins
Vpu NP_057855 Increased susceptibility of HIV-infected cells to Fas killing has been mapped to the HIV-1 vpu gene
Envelope surface glycoprotein gp160, precursor NP_057856 The calmodulin-binding domains in HIV-1 gp160 are involved in Fas-mediated apoptosis
Nef NP_057857 HIV-1 Nef interacts with ABCA1 and induces downregulation and redistribution of ABCA1 to the plasma membrane
matrix NP_579876 The localization of the HIV-1 reverse transcription complex to actin microfilaments is mediated by the interaction of a reverse transcription complex component (HIV-1 Matrix) with actin, but not vimentin (intermediate filaments) or tubulin (microtubules)
capsid NP_579880 Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen
nucleocapsid NP_579881 Mature HIV-1 Nucleocapsid, as well as the nucleocapsid domain of the HIV-1 Gag polyprotein, binds filamentous actin resulting in incorporation of actin into virus particles and enhancement of cell motility
p6 NP_579883 The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6
Envelope surface glycoprotein gp120 NP_579894 HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4
Envelope transmembrane glycoprotein gp41 NP_579895 The interaction of the long cytoplasmic tail of HIV-1 gp41 with the carboxy-terminal regulatory domain of p115-RhoGEF inhibits p115-mediated actin stress fiber formation and activation of serum response factor (SRF)
retropepsin NP_705926 The cleavage site of alpha 2-Macroglobulin by HIV-1 protease is the Phe684-Tyr685 bond
reverse transcriptase NP_705927 The localization of the HIV-1 reverse transcription complex to actin microfilaments is mediated by the interaction of a reverse transcription complex component (HIV-1 Matrix) with actin, but not vimentin (intermediate filaments) or tubulin (microtubules)
integrase NP_705928 PARP has been described as a requirement for efficient HIV-1 integration, however a conflicting report indicates it is not essential for efficient lentivirus integration
p1 NP_787042 HIV-1 p1 is mono- or di-ubiquitinated at levels comparable to those of the other HIV-2 Gag domains MA, CA, NC, and p6; cumulative replacement of all lysine residues in NC and p1 or in NC and p6 results in an accumulation of late budding structures
Pol NP_789740 The HIV-1 Pol 325-333 epitope binds strongly to HLA-A3 molecules and forms very stable complexes
[orthologue assignment]