| Protein name |
HIV ProteinID |
HIV Protein Description |
| Pr55(Gag) |
NP_057850 |
HIV-1 Gag binds to AP-2, and this binding is dependent on tyrosine residue 132 and valine residue 135 at the matrix-capsid junction in the Gag polyprotein |
| Vif |
NP_057851 |
Vif plays an important role in promoting HIV-1 binding to CD4 |
| Vpr |
NP_057852 |
HIV-1 Vpr-expressing Jurkat T cell clones showed a significant increase in G-actin polymerization to filamentous actin (F-actin), indicating a role of Vpr in microfilament system assembly. Vpr also causes disruption of the actin cytoskeleton in yeast. |
| Tat |
NP_057853 |
Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein |
| Rev |
NP_057854 |
Rev plays an important role in the compartmentation of translation by directing RRE-containing mRNAs to the beta-actin to form the perinuclear clusters at which the synthesis of viral structural proteins begins |
| Vpu |
NP_057855 |
Increased susceptibility of HIV-infected cells to Fas killing has been mapped to the HIV-1 vpu gene |
| Envelope surface glycoprotein gp160, precursor |
NP_057856 |
The calmodulin-binding domains in HIV-1 gp160 are involved in Fas-mediated apoptosis |
| Nef |
NP_057857 |
HIV-1 Nef interacts with ABCA1 and induces downregulation and redistribution of ABCA1 to the plasma membrane |
| matrix |
NP_579876 |
The localization of the HIV-1 reverse transcription complex to actin microfilaments is mediated by the interaction of a reverse transcription complex component (HIV-1 Matrix) with actin, but not vimentin (intermediate filaments) or tubulin (microtubules) |
| capsid |
NP_579880 |
Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen |
| nucleocapsid |
NP_579881 |
Mature HIV-1 Nucleocapsid, as well as the nucleocapsid domain of the HIV-1 Gag polyprotein, binds filamentous actin resulting in incorporation of actin into virus particles and enhancement of cell motility |
| p6 |
NP_579883 |
The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 |
| Envelope surface glycoprotein gp120 |
NP_579894 |
HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 |
| Envelope transmembrane glycoprotein gp41 |
NP_579895 |
The interaction of the long cytoplasmic tail of HIV-1 gp41 with the carboxy-terminal regulatory domain of p115-RhoGEF inhibits p115-mediated actin stress fiber formation and activation of serum response factor (SRF) |
| retropepsin |
NP_705926 |
The cleavage site of alpha 2-Macroglobulin by HIV-1 protease is the Phe684-Tyr685 bond |
| reverse transcriptase |
NP_705927 |
The localization of the HIV-1 reverse transcription complex to actin microfilaments is mediated by the interaction of a reverse transcription complex component (HIV-1 Matrix) with actin, but not vimentin (intermediate filaments) or tubulin (microtubules) |
| integrase |
NP_705928 |
PARP has been described as a requirement for efficient HIV-1 integration, however a conflicting report indicates it is not essential for efficient lentivirus integration |
| p1 |
NP_787042 |
HIV-1 p1 is mono- or di-ubiquitinated at levels comparable to those of the other HIV-2 Gag domains MA, CA, NC, and p6; cumulative replacement of all lysine residues in NC and p1 or in NC and p6 results in an accumulation of late budding structures |
| Pol |
NP_789740 |
The HIV-1 Pol 325-333 epitope binds strongly to HLA-A3 molecules and forms very stable complexes |
